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Wanted to stop. I knew I needed to stop. But I couldn stay clean to save my life, Mooney said. Accordingly, within patients with an IKZF1 deletion, those with ERGdel had a better outcome (8 y EFS: 85.7 vs 51.3 hazard louboutin soldes ratio: 0.16; 95 confidence interval: 0.02 P These findings have implications for further stratification including IKZF1 status.Keywords: B cell precursor acute lymphoblastic leukemia; molecular diagnostics; ERG; IKZF1Top of pageIntroductionAcute lymphoblastic leukemia (ALL) is the most common pediatric malignancy and comprises distinct entities characterized by recurring genetic longchamp pas cher alterations.1, 2, 3 These classifying alterations are associated with specific gene expression profiles and can influence the treatment response.4, 5 High hyperdiploidy and the chromosomal translocation t(12;21) are the most prevalent alterations in young children and are associated with good treatment response and outcome. However, in a significant fraction of pediatric cheap pandora charms BCP ALL, the genetic basis of the disease remains unknown and the outcome is unpredictable at the time of diagnosis. This is especially true for older children and adolescents, of whom more than half display no classifying genetic alteration.1 New biological markers are thus needed to help make treatment decisions and improve outcome in these patients.yi03.24

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