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Among the total group of patients, those who took PPIs were less likely to have vascular disease, cancer, diabetes, hypertension, and chronic obstructive pulmonary disease, but PPI use was linked with a 10% increased risk pandora charms sale of CKD and a 76% increased risk of dying prematurely."As a large number of patients are being treated with PPIs, health care providers need to be better educated about the potential side effects of these drugs, such as CKD," said Dr. Arora. "PPIs are often prescribed outside of their approved uses, and it has been estimated that up to two thirds of all people on PPIs do not have a verified louboutin pas cher indication for the drug."Studies: 1) "Proton Pump Inhibitor Use is Associated with Incident Chronic Kidney Disease" (Abstract SA OR005) 2) "Proton Pump Inhibitors Are Associated with Increased Risk of Development of Chronic Kidney Disease" (Abstract TH PO574).Disclosures: 1) Josef Coresh receives research funding from NKF and NIH, and is a scientific advisor to KDIGO.yi04.20